Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Genetic studies of manic–depressive illness

Inconclusive results from linkage studies of bipolar illness mirror the complexity of the disease.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Poe, E.A. The Fall of the House of Usher and Other Writings (1839; reprint, Penguin Books, London, 1986).

    Google Scholar 

  2. Goodwin, F.K. & Jamison, K.R. Manic-Depressive Illness. (Oxford University Press, New York, 1990).

    Google Scholar 

  3. Regier, D.A. et al. One-month prevalence of mental disorders in the United States: Based on five epidemiological catchment areas. Arch. Gen. Psychiatry 44, 977–986 (1988).

    Article  Google Scholar 

  4. Kessler, R.C. et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the national comorbidity survey. Arch. Gen. Psychiatry 51, 8–19 (1994).

    Article  CAS  Google Scholar 

  5. Angst, J. The course of major depression, atypical bipolar disorder, and bipolar disorder. in New Results in Depression Research, (eds. Hippius, H., Klerman, G.L. & Matussek, N.) (Springer-Verlag, Berlin, 1986).

    Google Scholar 

  6. Roy-Byrne, P., Post, R.M., Uhde, T.W., Porcu, T. & Davis, D. The longitudinal course of recurrent affective illness: Life chart data from research patients at the NIMH. Ada Psychiatr. Scand. 71 (suppl. 317), 1–34 (1985).

    Article  Google Scholar 

  7. Regier, D.A. et al. Co-morbidity of mental disorders with drug and alcohol abuse: Results from the Epidemiologic Catchment Area (EGA) study. JAMA 264, 2511–2518 (1990).

    Article  CAS  Google Scholar 

  8. Wyatt, R.L. & Henter, I. An economic evaluation of manic-depressive illness — 1991. Soc. Psychiatry Psychiatr. Epidemiol. 30, 213–219 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Blackwood, D.H.R. et al. A locus for bipolar affective disorder on chromosome 4p. Nature Genet. 12, 427–430 (1996).

    Article  CAS  Google Scholar 

  10. Ginns, E.I. A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nature Genet. 12, 431–435 (1996).

    Article  CAS  Google Scholar 

  11. Freimer, N.B. et al. Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22–q23. Nature Genet. 12, 436–441 (1996).

    Article  CAS  Google Scholar 

  12. Berrettini, W. et al. Chromosome 18 DNA markers and manic-depressive illness: Evidence for a susceptibility gene. Proc. Natl. Acad. Sci. USA 91, 5918–5921 (1994).

    Article  CAS  Google Scholar 

  13. Stine, O.C. et al. Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am. J. Hum. Genet. 57, 1384–1394 (1995).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Richards, R.L. Relationships between creativity and psychopathology: An evaluation and interpretation of the evidence. Genet. Psychol. Monogr. 103, 261–324 (1981).

    CAS  PubMed  Google Scholar 

  15. Jamison, K.R. Touched With Fire: Manic-Depressive Illness and the Artistic Temperament. (Free Press, New York, 1993).

    Google Scholar 

  16. Baxter, L.R. et al. Cerebral metabolic rates in mood disorders: Studies with positron emission tomography and fluorodeoxyglucose F18. Arch. Gen. Psychiatry 42, 441–447 (1985).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Jamison, K., McInnis, M. Genetic studies of manic–depressive illness. Nat Med 2, 521–522 (1996). https://doi.org/10.1038/nm0596-521

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0596-521

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing