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Nudging xenotransplantation towards humans

Nature Medicine volume 1, pages 403–404 (1995)Cite this article

Transplanting organs across species lines presents tremendous difficulties, but the obstacles are no longer insurmountable (pages 423–427).

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References

  1. Carrel, A. La technique operatoire des anastomoses vasculaires et la transplantation des visceres. Lyon Med. 98, 859–864 (1902)

    Google Scholar 

  2. Ullman, E. Experimented nierentransplantation. Wiener Klinische Wochenschrift 11, 281–282 (1902).

    Google Scholar 

  3. von Decastello, A. Ueber experimentelle nierentransplantation. Wiener Klinische Wochenschrift 12, 317 (1902).

    Google Scholar 

  4. Schwartz, R., Stack, J. & Dameshek, S. Effect of 6-mercaptopurine on antibody production. Proc. Soc. exp. Biol. 99, 164 (1958).

    Article  CAS  Google Scholar 

  5. Calne, R.Y. The rejection of renal homografts. Inhibition in dogs by 6-mercaptopurine. Lancet 1, 417–418 (1960).

    Article  CAS  Google Scholar 

  6. Zukowski, C.F., Lee, H.M. & Hume, D.M. The prolongation of functional survival of canine renal homografts by 6-mercaptopurine. Surg. Forum 11, 470 (1960).

    Google Scholar 

  7. McCurry, K.R. et al. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nature Med. 1, 423–427 (1995).

    Article  CAS  Google Scholar 

  8. Galili, U. Interaction of the natural anti-Gal antibody with a-galactosyl epitopes: A major obstacle for xenotransplantation in humans. Immun. Today 14, 480–482 (1993).

    Article  CAS  Google Scholar 

  9. Inverardi, L. & Pardi, R. Early events in cell-mediated recognition of vascularised xenografts: Cooperative interactions between selected lymphocyte subsets and natural antibodies. Immunol. Rev. 141, 71–93 (1994).

    Article  CAS  Google Scholar 

  10. Sandrin, M.S., Vaughan, H.A., Dabkowski, P.L. & McKenzie, I.F.C. IgM antibodies in human serum react predominantly with Gal(a1-3)Gal epitopes. Proc. natn. Acad. Sci. U.S.A. 90, 11391–11395 (1993).

    Article  CAS  Google Scholar 

  11. Gustafsson, K., Strahan, K. & Preece, A. a1,3 Galactosyltransferase: A target for in vivo genetic manipulation in xenotransplantation. Immunol. Rev. 141, 59–70 (1994).

    Article  CAS  Google Scholar 

  12. Sawyer, G.J., Gustafsson, K. & Fabre, J.W. Vascularised mouse-to-rat heart grafts: An unexpectedly difficult model of xenotransplantation. Transplantation Proc. 27 309 (1995).

    CAS  Google Scholar 

  13. Ullman, E. Tissue and organ transplantation. Ann. Surg. 60, 195–219 (1914).

    Article  CAS  Google Scholar 

Download references

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  1. Institute of Child Health, University of London, London, WC1N 1EH, UK

    John W. Fabre

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  1. John W. Fabre
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Fabre, J. Nudging xenotransplantation towards humans. Nat Med 1, 403–404 (1995). https://doi.org/10.1038/nm0595-403

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