Moderate to severe asthma is difficult to treat because recurring bouts of inflammation in the lungs induce fibrosis, which reduces lung elasticity, gas exchange and responses to conventional therapy. A recent study identifies the tumor necrosis factor family member LIGHT as an essential mediator of airway fibrosis in a mouse model of chronic asthma (pages 596–603).
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Wynn, T., Ramalingam, T. Shedding LIGHT on severe asthma. Nat Med 17, 547–548 (2011). https://doi.org/10.1038/nm0511-547
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DOI: https://doi.org/10.1038/nm0511-547
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