Although leukocyte activation in fat tissue promotes obesity-related insulin resistance, a role for B cells has been unclear. A new study in obese mice shows that they enter the fat tissue to activate T cell function and boost inflammation, exacerbating the metabolic disease (pages 610–617).
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Marina Corral
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Mallat, Z. The B-side story in insulin resistance. Nat Med 17, 539–540 (2011). https://doi.org/10.1038/nm0511-539
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DOI: https://doi.org/10.1038/nm0511-539
