Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

An array of possibilities for multiple sclerosis

Nature Medicine volume 8, pages 451–453 (2002)Cite this article

Brain lesions exhibiting inflammation and neuronal damage are an important part of the pathology of multiple sclerosis. Microarray analysis compares gene expression in two forms of these lesions, and points to new therapies for the disease. (pages 500–508)

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Understanding the differences between silent and acute MS lesions will help tailor therapies for distinct stages and forms of the disease.

References

  1. Lock, C. et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nature Med. 8, 500–508 (2002).

    Article  CAS  Google Scholar 

  2. Wekerle, H., Kojima, K., Lannes-Vieira, J., Lassmann, H. & Linington, C. Animal models. Ann. Neurol. 36 (Suppl.), S47–S53 (1994).

    Article  CAS  Google Scholar 

  3. Zavala, F. et al. G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine- and cytokine-based immune deviation. J. Immunol. 168, 2011–2019 (2002).

    Article  CAS  Google Scholar 

  4. Whitney, L.W. et al. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann. Neurol. 46, 425–428 (1999).

    Article  CAS  Google Scholar 

  5. Whitney, L.W., Ludwin, S.K., McFarland, H.F. & Biddison, W.E. Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions. J. Neuroimmunol. 121, 40–48 (2001).

    Article  CAS  Google Scholar 

  6. Ibrahim, S.M. et al. Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitis. Brain 124, 1927–1938 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Microbiology-Immunology and the Interdepartmental Immunobiology Center Northwestern University Medical School, Chicago, Illinois, USA

    Stephen M. Tompkins & Stephen D. Miller

Authors
  1. Stephen M. Tompkins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen D. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tompkins, S., Miller, S. An array of possibilities for multiple sclerosis. Nat Med 8, 451–453 (2002). https://doi.org/10.1038/nm0502-451

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0502-451

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing