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Bone cancer gain without the pain

In a newly developed model of bone cancer pain, a secreted ‘decoy’ tumor necrosis factor receptor protein, osteoprotegerin, blocks neurochemical signals in the spinal cord and pain associated with osteolytic metastases (pages 521–528).

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Figure 1: The possible mechanism of bone cancer pain.

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Thompson, S., Tonge, D. Bone cancer gain without the pain. Nat Med 6, 504–505 (2000). https://doi.org/10.1038/74977

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