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Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470

Nature Medicine volume 3, pages 443–446 (1997)Cite this article

Abstract

Angiogenesis, the growth of new blood vessels, occurs normally in female reproductive organs. We tested the hypothesis that angiogenesis inhibition may affect fertility by studying the reproductive system in either pregnant or nonpregnant cycling mice after treatment with the angiogenesis inhibitor AGM-1470. Administration of AGM-1470 to pregnant mice resulted in complete failure of embryonic growth due to interference with decidualization, placental and yolk sac formation, and embryonic vascular development. When nonpregnant cycling female mice were chronically treated with AGM-1470, inhibition of endometrial maturation and corpora lutea was observed. These data suggest that processes in reproduction can be controlled through angiogenesis inhibition.

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Authors and Affiliations

  1. Department of Surgery, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Nancy Klauber, Richard M. Rohan, Evelyn Flynn & Robert J. D'amato

  2. Department of Surgery, Boston University Medical Center, Boston, Massachusetts, 02118, USA

    Nancy Klauber

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  1. Nancy Klauber
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  2. Richard M. Rohan
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  3. Evelyn Flynn
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  4. Robert J. D'amato
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Klauber, N., Rohan, R., Flynn, E. et al. Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470. Nat Med 3, 443–446 (1997). https://doi.org/10.1038/nm0497-443

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