Tamoxifen and its analogues are powerful tools in the fight against breast cancer and may soon find applications fighting other diseases such as atherosclerosis and osteoporosis.
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References
Santambrogio, L. et al. Studies on the mechanisms by which transforming growth factor-β protects against allergic encephalomyelitis — antagonism between TGF-β and tumour necrosis factor. J. Immunol. 151, 116–1127 (1993).
Ward, R.L., Morgan, G.;., Dalley, D. & Kelly, P.J. Tamoxifen reduces bone turnover and prevents lumbar spine and proximal femoral bone loss in early postmenopausal women. Bone Miner. 22, 87–94 (1993).
Grainger, D.J., Witchell, C.M. & Metcalfe, J.C. Tamoxifen elevates transforming growth factor-β and suppresses diet-induced formation of lipid lesions in mouse aorta. Nature Med. 1, 1067–1072 (1995).
van Leeuwen, F.E. et al. Risk of endometrial cancer after tamoxifen treatment of breast cancer. Lancet 343, 448–452 (1994).
Rutquist, L.E. et al. Adjuvant tamoxifen therapy for early-stage breast cancer and second primary malignancies. J. Natl Cancer Inst. 87, 645–651 (1995).
Potter, G.A., McCague, R. & Jarman, M. A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism. Carcinogenesis 15, 439–442 (1994).
Karnik, P.S., Kulkarni, S., Liu, X.P., Budd, G.T. & Bukowski, R.M. Estrogen-receptor mutations in tamoxifen resistant breast cancer. Cancer Res. 54, 349–353 (1994).
Colletta, A.A. et al. Anti-oestrogens induce the secretion of active transforming growth factor β from human fetal fibroblasts. Br. J. Cancer 62, 405–409 (1990).
Jeng, M.H., Tendijke, P., Iwata, K.K. & Jordan, V.C. Regulation of the levels of three transforming growth factor-β mRNAs by estrogen and their effects on the proliferation of human breast cancer cells. Mol Cell. Endocrinol. 92, 115–123 (1993).
Butta, A. et al. Induction of transforming growth factor β1 in human breast cancer in vivo following tamoxifen treatment. Cancer Res. 52, 4261–4264 (1992).
Markowitz, S. et al. Inactivation of the type II TGF-β receptor in colon cancer cells with micro-satellite instability. Science 268, 1336–1338 (1995).
Pierce, D.F. et al. Mammary tumour suppression by transforming growth factor β1 transgene expression. Proc. Natl. Acad. Sci. USA 92, 4254–4258 (1995).
Torre-Amione, G. et al. A highly immunogenic tumour transfected with a murine transforming growth factor type β1 cDNA escapes immune surveillance. Proc. Natl. Acad. Sci. USA 87, 1486–1490 (1990).
Langdahl, B.L., Brixen, K., Jensen, H.K., Gregersen, N. & Eriksen, E.F. Mutations in the TGF-beta-1 gene are correlated to low bone mass and increased bone turnover. J. Bone Mineral Res. 10, abstract 185 (1995).
MacDonald, C.C. & Stewart, H.J. Fatal myocar-dial infarction in the Scottish adjuvant tamoxifen trial. Br. Med. J. 303, 435–437 (1991).
MacDonald, C.C., Alexander, F.E., Whyte, B.W., Forrest, A.P. & Stewart, H.J. Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomised trial. Brit. Med.J. 311, 977–980 (1995).
Grainger, D.J. Metcalfe, J.C. DJ Metcalfe, J.C. A pivotal role for TGF-β in atherogenesis? Biol. Rev. Camb. Philos. Soc. 70, 571–596 (1995).
Grainger, D.J., Kemp, P.R., Liu, A.C., Lawn, R.M. & Metcalfe, J.C. Activation of transforming growth factor β is inhibited in transgenic apolipopro-tein(a) mice. Nature 370, 460–462 (1994).
Stein, B. & Yang, M.X. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NFKB and C/EBPβ. Mol. Cell. Biol. 15, 4971–4979 (1995).
Caldenhoven, E. et al. Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the anti-inflammatory action of glucocorticoids. Mol. Endocrinol. 9, 401–412 (1995).
Mauviel, A., Chen, Y.Q., Dong, W., Evans, C.H. & Ditto, J. Transcriptional interactions of TGF-p with pro-inflammatory cytokines. Curr. Biol. 3, 822–831 (1993).
Border, W.A. & Noble, N.A., TGF-β for treatment of disease. Nature Med. 1, 1000–1001 (1995).
Magarian, R.A., Overacre, L.B., Singh, S. & Meyer, K.L. The medicinal chemistry of non-steroidal antiestrogens: A review. Curr. Med. Chem. 1, 61–104 (1994).
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Grainger, D., Metcalfe, J. Tamoxifen: Teaching an old drug new tricks?. Nat Med 2, 381–385 (1996). https://doi.org/10.1038/nm0496-381
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DOI: https://doi.org/10.1038/nm0496-381
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