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Derailing heterotopic ossification and RARing to go

Nature Medicine volume 17, pages 420421 (2011) | Download Citation

Retinoic acid receptors inhibit chondrogenesis, but their ability to block the cartilaginous scaffold of heterotopic endochondral ossification has not been explored. A study in mice shows that agonists of retinoic acid receptor-γ potently inhibit heterotopic endochondral ossification, suggesting therapeutic potential in people with this condition (pages 454–460).

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References

  1. 1.

    et al. Clin. Rev. Bone Miner. Metab. 3, 261–266 (2005).

  2. 2.

    et al. Nat. Genet. 38, 525–527 (2006); erratum 39, 276 (2007).

  3. 3.

    et al. Cytokine Growth Factor Rev. 20, 399–407 (2009).

  4. 4.

    & Nat. Rev. Rheumatol. 6, 518–527 (2010).

  5. 5.

    et al. Circulation 103, 1522–1528 (2001).

  6. 6.

    et al. Nat. Med. 16, 1400–1406 (2010).

  7. 7.

    et al. Cytokine Growth Factor Rev. 20, 409–418 (2009).

  8. 8.

    et al. Nat. Med. 17, 454–460 (2011)

  9. 9.

    et al. Clin. Orthop. Relat. Res. 346, 121–129 (1998).

  10. 10.

    et al. J. Cell Biol. 174, 101–113 (2006).

  11. 11.

    et al. Proc. Natl. Acad. Sci. USA 107, 18886–18891 (2010).

  12. 12.

    et al. BMC Biol. 7, 67 (2009).

  13. 13.

    et al. J. Biol. Chem. 285, 317–327 (2010).

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Author information

Affiliations

  1. Frederick S. Kaplan is at the Departments of Orthopedic Surgery and Medicine and the Center for Research in FOR and Related Disorders, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    • Frederick S Kaplan
  2. Eileen M. Shore is at the Departments of Orthopedic Surgery and Genetics and the Center for Research in FOP and Related Disorders, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

    • Eileen M Shore

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  1. Search for Frederick S Kaplan in:

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Frederick S Kaplan.

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DOI

https://doi.org/10.1038/nm0411-420

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