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Robo4 counteracts VEGF signaling

Robo4 expression in emerging blood vessels can neutralize signaling through the angiogenic factor vascular endothelial growth factor (VEGF) and maintain vessel integrity. The findings could lead to new therapeutic targets for angiogenesis and vascular leakage (pages 448–453).

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Figure 1: The work of Jones et al.3

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Acevedo, L., Weis, S. & Cheresh, D. Robo4 counteracts VEGF signaling. Nat Med 14, 372–373 (2008).

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