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New drugs for an ancient parasite

Only one drug is widely used to treat schistosomiasis, a chronic, neglected tropical disease caused by parasitic blood flukes. Fears of potential drug resistance have accelerated the search for new classes of antischistosome drugs. A promising candidate has now emerged (pages 407–412).

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Figure 1

Venkatraman R. Vydianathapuram

Figure 2: An integrated approach is needed to eliminate schistosomiasis.

References

  1. King, C.H., Dickman, K. & Tisch, D.J. Lancet 365, 1561–1569 (2005).

    Article  Google Scholar 

  2. Finkelstein, J.L., Schleinitz, M.D., Carabin, H. & McGarvey, S.T. PLoS Negl. Trop. Dis. 2, e158 (2008).

    Article  Google Scholar 

  3. Sayed, A.A. et al. Nat. Med. 14, 407–412 (2008).

    Article  CAS  Google Scholar 

  4. World Health Organization. WHO Model List of Essential Medicines, 15th edn., 1–27 (World Health Organization, Geneva, 2007).

  5. Fenwick, A. Science 313, 1077–1081 (2006).

    Article  CAS  Google Scholar 

  6. Fallon, P.G. & Doenhoff, M.J. Am. J. Trop. Med. Hyg. 51, 83–88 (1994).

    Article  CAS  Google Scholar 

  7. Inglese, J. et al. Proc. Natl. Acad. Sci. USA 103, 11473–11478 (2006).

    Article  CAS  Google Scholar 

  8. Alger, H.M. & Williams, D.L. Mol. Biochem. Parasitol. 121, 129–139 (2002).

    Article  CAS  Google Scholar 

  9. Simeonov, A. et al. PLoS Negl. Trop. Dis. 2, e127 (2008).

    Article  Google Scholar 

  10. van der Werf, M.J. et al. Acta Trop. 86, 125–139 (2003).

    Article  Google Scholar 

  11. Croft, S.L. Trans. R. Soc. Trop. Med. Hyg. 99 Suppl 1, S9–S14 (2005).

    Article  Google Scholar 

  12. McManus, D.P. & Loukas, A. Clin. Microbiol. Rev. 21, 225–242 (2008).

    Article  CAS  Google Scholar 

Download references

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Loukas, A., Bethony, J. New drugs for an ancient parasite. Nat Med 14, 365–367 (2008). https://doi.org/10.1038/nm0408-365

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