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Immune to the high

Current medications used to treat drug addiction help to some extent by easing withdrawal symptoms, but these treatments cannot curb the high that people receive when they relapse and take a hit of the drug. Emma Marris explores how researchers are working on a way to make these tempting drug highs history for recovering addicts.

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  1. Bonese, K.F., Wainer, B.H., Fitch, F.W., Rothberg, R.M. & Schuster, C.R. Nature 252, 708–710 (1974).

    Article  CAS  Google Scholar 

  2. Owens, S.M. & Mayersohn, M. Drug Metab. Dispos. 14, 52–58 (1986).

    CAS  PubMed  Google Scholar 

  3. Davis, R. Annu. Rev. Public Health 28, 171–194 (2007).

    Article  Google Scholar 

  4. Rigotti, N.A. N. Engl. J. Med. 346, 506–512 (2002).

    Article  Google Scholar 

  5. Laurenzana, E. J. Pharmacol. Exp. Ther. 306, 1092–1098 (2003).

    Article  CAS  Google Scholar 

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Marris, E. Immune to the high. Nat Med 14, 358–361 (2008).

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