'Impulsivity' occurs frequently in people with addiction and other common disorders such as attention deficit hyperactivity disorder (ADHD). Experiments in rats suggest that reduced dopamine receptor availability in the brain's ventral striatum may underlie links between impulsivity and addiction.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dalley, J.W. et al. Science 315, 1267–1270 (2007).
Regier, D.A. et al. J. Am. Med. Assoc. 264, 2511–2518 (1990).
Uhl, G.R. NeuroRx 3, 295–301 (2006).
Volkow, N.D. et al. Synapse 46, 79–82 (2002).
Smith, S.S. et al. Arch. Gen. Psychiatry 49, 723–727 (1992).
Xu, K. et al. Arch. Gen. Psychiatry 61, 597–606 (2004).
Gelernter, J. et al. Hum. Mol. Genet. 15, 3498–3507 (2006).
Winstanley, C.A., Eagle, D.M. & Robbins, T.W. Clin. Psychol. Rev. 26, 379–395 (2006).
Robbins, T.W. Psychopharmacology (Berl.) 163, 362–380 (2002).
Reynolds, B. Behav. Pharmacol. 17, 651–667 (2006).
Hyman, S.E., Malenka, R.C. & Nestler, E.J. Annu. Rev. Neurosci. 29, 565–598 (2006).
Clark, L., Robbins, T.W., Ersche, K.D. & Sahakian, B.J. Biol. Psychiatry 60, 515–522 (2006).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Uhl, G. Premature poking: impulsivity, cocaine and dopamine. Nat Med 13, 413–414 (2007). https://doi.org/10.1038/nm0407-413
Issue Date:
DOI: https://doi.org/10.1038/nm0407-413
This article is cited by
-
The role of impulsive behavior in drug abuse
Psychopharmacology (2008)