Chemokines in the brain recruit immune cells from the blood or from within the brain. Disrupting this line of communication exacerbates disease in mouse models of Alzheimer disease (pages 432–438).
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
When the infectious environment meets the AD brain
Molecular Neurodegeneration Open Access 19 August 2022
-
Plasma MCP-1 and changes on cognitive function in community-dwelling older adults
Alzheimer's Research & Therapy Open Access 07 January 2022
-
Plasma MCP-1 and Cognitive Decline in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: A Two-year Follow-up Study
Scientific Reports Open Access 19 January 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Akiyama, H. et al. Neurobiol. Aging 21, 383–421 (2000).
Rebenko-Moll, N.M., Liu, L., Cardona, A. & Ransohoff, R.M. Curr. Opin. Immunol. 18, 683–689 (2006).
Wyss-Coray, T. Nat. Med. 12, 1005–1015 (2006).
El Khoury, J. et al. Nat. Med. 13, 432–438 (2007).
Blennow, K., de Leon, M.J. & Zetterberg, H. Lancet 368, 387–403 (2006).
McGowan, E. et al. Neuron 47, 191–199 (2005).
Simard, A.R., Soulet, D., Gowing, G., Julien, J.P. & Rivest, S. Neuron 49, 489–502 (2006).
Tanzi, R.E., Moir, R.D. & Wagner, S.L. Neuron 43, 605–608 (2004).
Iwata, N. et al. Nat. Med. 6, 143–150 (2000).
Leissring, M.A. et al. Neuron 40, 1087–1093 (2003).
Yamamoto, M. et al. Am. J. Pathol. 166, 1475–1485 (2005).
Huang, D. et al. FASEB J. 19, 761–772 (2005).
Charo, I.F. & Ransohoff, R.M. N. Engl. J. Med. 354, 610–621 (2006).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Britschgi, M., Wyss-Coray, T. Immune cells may fend off Alzheimer disease. Nat Med 13, 408–409 (2007). https://doi.org/10.1038/nm0407-408
Issue Date:
DOI: https://doi.org/10.1038/nm0407-408
This article is cited by
-
When the infectious environment meets the AD brain
Molecular Neurodegeneration (2022)
-
Plasma MCP-1 and changes on cognitive function in community-dwelling older adults
Alzheimer's Research & Therapy (2022)
-
Plasma MCP-1 and Cognitive Decline in Patients with Alzheimer’s Disease and Mild Cognitive Impairment: A Two-year Follow-up Study
Scientific Reports (2018)
-
Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology
Nature Communications (2015)
-
Differential distribution and activation of microglia in the brain of male C57BL/6J mice
Brain Structure and Function (2013)