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Protein twists and turns in Alzheimer disease

An enzyme that modifies protein structure seems to help keep Alzheimer disease at bay. The enzyme affects two proteins thought to be key to disease pathology: amyloid precursor protein (APP) and the microtubule-binding protein tau.

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Figure 1: Pin-mediated prolyl isomerization in proteolytic processing of the amyloid precursor protein and cell cycle regulation.

Katie Ris

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Maudsley, S., Mattson, M. Protein twists and turns in Alzheimer disease. Nat Med 12, 392–393 (2006). https://doi.org/10.1038/nm0406-392

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