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The skinny on CD39 in immunity and inflammation

Nature Medicine volume 8, pages 336–338 (2002)Cite this article

The finding that CD39 on Langerhans cells modulates inflammation and immunity in the skin might lead to new strategies to alter immune responses to benefit patients and suggests a new in vitro technique for assessing the irritant potential of topical agents. (pages 358–365)

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Figure 1: T-cell signaling of dendritic antigen-presenting cells via ATP.

Bob Crimi

References

  1. Langerhans, P. Über die Nerven der menschlichen Haut. Virchows Arch. Pathol. Anat. Physiol. Klin. Med. 44, 325–337 (1868).

    Article  Google Scholar 

  2. Stingl, G. et al. Immunologic functions of Ia-bearing epidermal Langerhans cells. J. Immunol. 121, 2005–2013 (1978).

    CAS  PubMed  Google Scholar 

  3. Silberberg, I., Baer, R.L., Rosenthal, A.S. The role of Langerhans cells in allergic contact hypersensitivity. A review of findings in man and guinea pigs. 1976. J. Invest. Dermatol. 66, 210–217 (1989).

    Article  Google Scholar 

  4. Stingl, G., Katz, S.I., Shevach, E.M., Rosenthal, A.S. & Green, I. Analogous functions of macrophages and Langerhans cells in the initiation in the immune response. J. Invest. Dermatol. 71, 59–64 (1978).

    Article  CAS  Google Scholar 

  5. Grabbe, S. & Granstein, R.D. Mechanisms of ultraviolet radiation carcinogenesis. Chem. Immunol. 58, 291–313 (1994).

    CAS  PubMed  Google Scholar 

  6. Mizumoto, N. et al. CD39 is the dominant Langerhans cell-associated ecto-NTPDase: Modulatory roles in inflammation and immune responsiveness. Nature Med. 8, 358–365 (2002).

    Article  CAS  Google Scholar 

  7. Wolff, K. & Winkelmann, R.K. Ultrastructural localization of nucleoside triphosphatase in Langerhans cells. J. Invest. Dermatol. 48, 50–54 (1967)

    Article  CAS  Google Scholar 

  8. Maliszewski, C.R. et al. the CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J. Immunol. 146, 2235–2244 (1991).

    Google Scholar 

  9. Coutinho-Silva, R. et al. P2Z/P2X7 receptor-dependent apoptosis of dendritic cells. Am. J. Physiol. 276, C1139–C1147 (1999).

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  1. Department of Dermatology Weill Medical College of Cornell University, New York, New York, USA

    Richard D. Granstein

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  1. Richard D. Granstein
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Granstein, R. The skinny on CD39 in immunity and inflammation. Nat Med 8, 336–338 (2002). https://doi.org/10.1038/nm0402-336

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