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Reply to 'Dyslipidemia due to retroviral protease inhibitors'

Nature Medicine volume 8, pages 308–309 (2002)Cite this article

Sturley et al. reply

The major issue raised by Kelleher et al. regards the pharmokinetics of HIV protease inhibitors such as ritonavir, saquinavir, indinavir and nelfinavir. They contend that the con-centrations used in our experiments—particularly those demonstrating proteasomal inhibition—are non-physiological. On this basis they argue that the inhibition of the proteasome is a minor contributor to the hyperlipidemic syndrome induced by these pharmaceuticals.

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References

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Authors and Affiliations

  1. Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York, USA

    Stephen L. Sturley & Richard J. Deckelbaum

  2. Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, New York, USA

    Stephen L. Sturley, Oliver Distler & Richard J. Deckelbaum

  3. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA

    Jun-Shan Liang & Henry N. Ginsberg

  4. National Center in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia

    Oliver Distler & David A. Cooper

  5. Stephen L. Sturley

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  1. Stephen L. Sturley
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  2. Oliver Distler
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  5. Richard J. Deckelbaum
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  6. Henry N. Ginsberg
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Sturley, S., Distler, O., Liang, JS. et al. Reply to 'Dyslipidemia due to retroviral protease inhibitors'. Nat Med 8, 308–309 (2002). https://doi.org/10.1038/nm0402-308b

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