Many mechanisms have been proposed for the positive effects of monoclonal antibodies in cancer therapy. New data indicate that both the variable, antigen-binding region of an antibody and the Fc region are capable of influencing anti-cancer immunity (pages 443–446).
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Houghton, A., Scheinberg, D. Monoclonal antibody therapies–a ‘constant’ threat to cancer. Nat Med 6, 373–374 (2000). https://doi.org/10.1038/74621
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DOI: https://doi.org/10.1038/74621
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