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Implicating PARP and NAD+ depletion in type I diabetes


Mice deficient in the PARP DNA repair enzyme are refractory to toxin-induced death of pancreatic beta cells and do not become diabetic (pages 314–319).

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Charron, M., Bonner-Weir, S. Implicating PARP and NAD+ depletion in type I diabetes . Nat Med 5, 269–270 (1999).

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