It is unclear whether modified immunoglobulins are at least partially responsible for rheumatoid arthritis (pages 237–243) or only an effect of the disease.
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Ezekowitz, R. Agalactosyl IgG and mannose-binding proteins: Biochemical nicety or pathophysiological paradigm?. Nat Med 1, 207–208 (1995). https://doi.org/10.1038/nm0395-207
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DOI: https://doi.org/10.1038/nm0395-207