Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Agalactosyl IgG and mannose-binding proteins: Biochemical nicety or pathophysiological paradigm?

It is unclear whether modified immunoglobulins are at least partially responsible for rheumatoid arthritis (pages 237–243) or only an effect of the disease.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Malhotra, R., Wormald, M.R., Rudd, P.M., Fischer, P.B., Dwek, R.A. & Sim, R.B. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nature Med. 1, 237–243 (1995).

    Article  CAS  Google Scholar 

  2. Parekh, R.B. et al. Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 316, 452–457 (1985).

    Article  CAS  Google Scholar 

  3. Drickamer, K. & Taylor, M.E. Biology of animal lectins. Annu. Rev. Cell Biol. 9, 237–264 (1993).

    Article  CAS  Google Scholar 

  4. Lu, J.H., Thiel, S., Wiedmann, H., Timpl, R. & Reid, K.B. Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2C1s2 complex of the classical pathway of complement without involvement of C1q . J. Immun. 144, 2287–2294 (1990).

    CAS  PubMed  Google Scholar 

  5. Ezekowitz, R.A.B. Ante-antibody immunity. Current Biol. 1, 60–62 (1991).

    Article  CAS  Google Scholar 

  6. Sastry, K. & Ezekowitz, R.A.B. Collectins: pattern recognition molecules involved in first line host defense. Curr. Opin. Immun. 5, 59–66 (1993).

    Article  CAS  Google Scholar 

  7. Schweinle, J., Ezekowitz, R.A.B., Tenner, A. & Joiner, K. Human mannose-binding protein activates the alternative complement pathway and enhances serum bactericidal activity on a man-nose-rich isolate of Salmonella. J. clin. Invest. 84, 1821–1829 (1989).

    Article  CAS  Google Scholar 

  8. Ikeda, K., Sannoh, T., Kawasaki, N., Kawasaki, T. & Yamashina, I. Serum lectin with known structure activates complement through the classical pathway. J. biol. Chem. 262, 7451 (1987).

    CAS  PubMed  Google Scholar 

  9. Matsushita, M. & Fujita, T. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J. exp. Med. 176, 1497–1502 (1992).

    Article  CAS  Google Scholar 

  10. Weis, W.I., Drickamer, K. & Hendrickson, W.A. Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature 360, 127–134 (1992).

    Article  CAS  Google Scholar 

  11. Super, M. et al. Distinct and overlapping functions of allelic forms of human mannose-binding protein. Nature Genet. 2, 50–55 (1992).

    Article  CAS  Google Scholar 

  12. Super, M., Thiel, S., Lu, J. & Turner, M.W. Association of low levels of mannan-binding protein with a common defect of opsonization. Lancet ii (8674), 1236–1238 (1989).

    Article  Google Scholar 

  13. Hartshorn, K.L. et al. Human mannose-binding protein serves as an opsonin for influenza A. J. Clin. Invest. 91, 1414–1420 (1993).

    Article  CAS  Google Scholar 

  14. Anders, E.M., Hartley, C.A., Reading, P.C. & Ezekowitz, R.A.B. Complement-dependent neutralization of influenza virus by a serum mannose-binding lectin. J. gen. Virol. 75, 615–622 (1994).

    Article  CAS  Google Scholar 

  15. Duncan, A.R. & Winter, G. The binding site for C1q on IgG. Nature 332, 738–740 (1988).

    Article  CAS  Google Scholar 

  16. Sheriff, S., Chang, C.Y. & Ezekowitz, R.A.B. Human mannose-binding protein carbohydrate recognition domain trimerizes through triple α-helical coiled-coil. Nature struct Biol. 1, 789–794 (1994).

    Article  CAS  Google Scholar 

  17. Weis, W.I. & Drickamer, K. Trimeric structure of a C-type mannose-binding protein. Current Biol. 2, 1227–1240 (1994).

    CAS  Google Scholar 

  18. Sumiya, M. et al. Molecular basis of opsonic defect in immunodeficient children. Lancet 337, 1569–1570 (1991).

    Article  CAS  Google Scholar 

  19. Matsushita, M., Ezekowitz, R.A.B. & Fujita, T. An allelic form of human mannose-binding protein (MBP) fails to bind to mannose-binding protein-associated serine protease (MASP). (submitted).

  20. Madsen, H.O. et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 40, 37–44 (1994).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ezekowitz, R. Agalactosyl IgG and mannose-binding proteins: Biochemical nicety or pathophysiological paradigm?. Nat Med 1, 207–208 (1995). https://doi.org/10.1038/nm0395-207

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0395-207

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing