A remote, downstream event in the pathology of muscular dystrophy may have a key role in the disease (pages 325–330). It seems that induction of nitric oxide synthase causes calcium to leak inside the cell through ryanodine receptors. The findings provide new options for therapeutic interventions.
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References
Petrof, B.J. et al. Proc. Natl. Acad. Sci. USA 90, 3710–3714 (1993).
Bellinger, A.M. et al. Nat. Med. 15, 325–330 (2009).
Ganster, R.W. et al. Proc. Natl. Acad. Sci. USA 98, 8638–8643 (2001).
Wehling, M. et al. J. Cell Biol. 155, 123–131 (2001).
Radley, H.G. et al. Neuromusc. Disord. 18, 227–238 (2008).
Messina, S. et al. Exp. Neurol. 198, 234–241 (2006).
Villalta, S.A. et al. Hum. Mol. Genet. 18, 482–496 (2009).
Stahn, C. & Buttgereit, F. Nat. Clin. Pract. Rheumatol. 4, 525–533 (2008).
Mokri, B. & Engel, A.G. Neurology 25, 1111–1120 (1975).
Turner, P.R. et al. J. Cell Biol. 115, 1701–1712 (1991).
Yeung, E.W. et al. J. Physiol. (Lond.) 562, 367–380 (2005).
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Tidball, J., Villalta, S. NO may prompt calcium leakage in dystrophic muscle. Nat Med 15, 243–244 (2009). https://doi.org/10.1038/nm0309-243
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DOI: https://doi.org/10.1038/nm0309-243
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