Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Taking two cuts at pain

Matrix metalloproteases (MMPs) are shedding their traditional roles in tissue remodeling and appearing as players in diseases of the nervous system. MMP2 and MMP9 provide the latest example, with converging roles in chronic pain after peripheral nerve injury (pages 331–336).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Pain players.

Katie Ris-Vicari


  1. Baron, R. Nat. Clin. Pract. Neurol. 2, 95–106 (2006).

    Article  Google Scholar 

  2. Marchand, F. et al. Nat. Rev. Neurosci. 6, 521–532 (2005).

    CAS  Article  Google Scholar 

  3. Tsuda, M. et al. Trends Neurosci. 28, 101–107 (2005).

    CAS  Article  Google Scholar 

  4. Kawasaki, Y. et al. Nat. Med. 14, 331–336 (2008).

    CAS  Article  Google Scholar 

  5. Yong, V.W. Nat. Rev. Neurosci. 6, 931–944 (2005).

    CAS  Article  Google Scholar 

  6. Sweitzer, S. et al. Neuroscience 103, 529–539 (2001).

    CAS  Article  Google Scholar 

  7. Page-McCaw, A. et al. Nat. Rev. Mol. Cell Biol. 8, 221–233 (2007).

    CAS  Article  Google Scholar 

  8. Scholz, J. & Woolf, C.J. Nat. Neurosci. 10, 1361–1368 (2007).

    CAS  Article  Google Scholar 

  9. Coull, J.A. et al. Nature 438, 1017–1021 (2005).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Beggs, S., Salter, M. Taking two cuts at pain. Nat Med 14, 243–244 (2008).

Download citation

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing