The genomic region lost during the attenuation of BCG vaccine encodes a newly discovered secretion system conserved among gram-positive bacteria. A series of papers has now dissected the components of this system, revealing a unique Mycobacterium tuberculosis–specific signal for export of bacterial proteins into the host.
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References
Mahairas, G.G., Sabo, P.J., Hickey, M.J., Singh, D.C. & Stover, C.K. J. Bacteriol. 178, 1274–1282 (1996).
Behr, M.A. et al. Science 284, 1520–1523 (1999).
Brodin, P. et al. Infect. Immun. 70, 5568–5578 (2002).
Mostowy, S., Cousins, D. & Behr, M.A. J. Bacteriol. 186, 104–109 (2004).
Pym, A.S., Brodin, P., Brosch, R., Huerre, M. & Cole, S.T. Mol. Microbiol. 46, 709–717 (2002).
Lewis, K.N. et al. J. Infect. Dis. 187, 117–123 (2003).
Hsu, T. et al. Proc. Natl. Acad. Sci. USA 100, 12420–12425 (2003).
Stanley, S.A., Raghavan, S., Hwang, W.W. & Cox, J.S. Proc. Natl. Acad. Sci. USA 100, 13001–13006 (2003).
MacGurn, J.A., Raghavan, S., Stanley, S.A. & Cox, J.S. Mol. Microbiol. 57, 1653–1663 (2005).
Champion, P.A., Stanley, S.A., Champion, M.M., Brown, E.J. & Cox, J.S. Science 313, 1632–1636 (2006).
Pym, A.S. et al. Nat. Med. 9, 533–539 (2003).
Guinn, K.M. et al. Mol. Microbiol. 51, 359–370 (2004).
Gey van Pittius, N.C. et al. Genome Biol. [online] 2 (2001) (doi:10.1186/gb-2001-2-10-research0044).
Sassetti, C.M. & Rubin, E.J. Proc. Natl. Acad. Sci. USA 100, 12989–12994 (2003).
Fortune, S.M. et al. Proc. Natl. Acad. Sci. USA 102, 10676–10681 (2005).
Mostowy, S., Tsolaki, A.G., Small, P.M. & Behr, M.A. Vaccine 21, 4270–4274 (2003).
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Behr, M., Sherman, D. Mycobacterial virulence and specialized secretion: same story, different ending. Nat Med 13, 286–287 (2007). https://doi.org/10.1038/nm0307-286
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DOI: https://doi.org/10.1038/nm0307-286
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