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Long-distance affair with adrenal GRK2 hangs up heart failure

Modulation of events regulated by α2-adrenergic receptors counteracts heart failure by restoring proper signaling from the adrenal gland to the heart (pages 315–323).

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Figure 1: Analogy between a G protein–coupled receptor module and a conventional stereo-audio amplifier.

Katie Ris

References

  1. Liggett, S.B. J. Clin. Invest. 107, 947–948 (2001).

    Article  CAS  Google Scholar 

  2. Lymperopoulos, A. et al. Nat. Med. 13, 315–323 (2007).

    Article  CAS  Google Scholar 

  3. Cohn, J.N. et al. N. Engl. J. Med. 311, 819–823 (1984).

    Article  CAS  Google Scholar 

  4. Lowes, B.D. et al. J. Heart Lung Transplant. 25, 579–588 (2006).

    Article  Google Scholar 

  5. Lefkowitz, R.J. et al. Mol. Cell 24, 643–652 (2006).

    Article  CAS  Google Scholar 

  6. Jewell-Motz, E.A. et al. Biochemistry 36, 8858–8863 (1997).

    Article  CAS  Google Scholar 

  7. Jewell-Motz, E.A. et al. Biochemistry 37, 15720–15725 (1998).

    Article  CAS  Google Scholar 

Download references

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Liggett, S. Long-distance affair with adrenal GRK2 hangs up heart failure. Nat Med 13, 246–248 (2007). https://doi.org/10.1038/nm0307-246

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