A small peptide administered into the brain of rats seems to abolish the rewarding effects of nicotine and THC. The peptide disrupts the interaction between a receptor for serotonin on dopamine-containing neurons and the tumor suppressor PTEN (pages 324–329).
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Thomas, K. Plot against pot. Nat Med 12, 281–283 (2006). https://doi.org/10.1038/nm0306-281
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DOI: https://doi.org/10.1038/nm0306-281