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Multiple sclerosis: trapped in deadly glue

Nature Medicine volume 11, pages 252–253 (2005)Cite this article

Two forms of glial cells have distinct roles in the neuroinflammatory cascade of a mouse model of multiple sclerosis. These cells serve as key targets for therapeutic intervention (pages 328–334 and 335–339).

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Figure 1: Neuroinflammation in EAE requires multiple steps of CD4+ T cell activation in distinct CNS compartments.

Deborah Maizels

References

  1. Carson, M.J., Reilly, C.R., Sutcliffe, J.G. & Lo, D. Glia 22, 72–85 (1998).

    Article  CAS  PubMed  Google Scholar 

  2. Cogle, C.R. et al. Lancet 363, 1432–1437 (2004).

    Article  CAS  PubMed  Google Scholar 

  3. Eglitis, M.A. & Mezey, E. Proc. Natl. Acad. Sci. USA 94, 4080–4085 (1997).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Jordan, F.L. & Thomas, W.E. Brain Res. 472, 165–178 (1988).

    Article  CAS  PubMed  Google Scholar 

  5. Carson, M.J. Glia 40, 218–231 (2002).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Greter, M. et al. Nat. Med. 11, 328–334 (2005).

    Article  CAS  PubMed  Google Scholar 

  7. Heppner, F.L. et al. Nat. Med. 11, 146–152 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. McMahon, E.J. et al. Nat. Med. 11, 335–339 (2005).

    Article  CAS  PubMed  Google Scholar 

  9. Hickey, W.F. & Kimura, H. Science 239, 290–292 (1988).

    Article  CAS  PubMed  Google Scholar 

  10. Slavin A.J. J. Clin. Inv. 108, 1135–1139 (2001).

    Article  Google Scholar 

  11. Becher, B., Durell, B.G. & Noelle, R.J. J. Clin. Invest. 112, 1186–1191 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Chabas, D. et al. Science 294, 1731–1735 (2001).

    Article  CAS  PubMed  Google Scholar 

  13. Yednock, T.A. et al. Nature 356, 63–66 (1992).

    Article  CAS  PubMed  Google Scholar 

  14. Brocke, S., Piercy, C., Steinman, L., Weissman, I.L. & Veromaa, T. Proc. Natl. Acad. Sci. USA 96, 6896–6901 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Miller, D.H. et al. N. Engl. J. Med. 348, 15–23 (2003).

    Article  CAS  PubMed  Google Scholar 

  16. Gordon, E.J., Myers, K.J., Dougherty, J.P., Rosen, H. & Ron, Y. J. Neuroimmunol. 62, 153–160 (1995).

    Article  CAS  PubMed  Google Scholar 

  17. Lovett-Racke, A.E. et al. J. Immunol. 172, 5790–5798 (2004).

    Article  CAS  PubMed  Google Scholar 

  18. Youssef, S. et al. Nature 420, 78–84 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Neurology, Department of General Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

    Michael Platten

  2. Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine and the Interdepartmental Program in Immunology, Stanford University, Stanford, California, USA

    Lawrence Steinman

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  1. Michael Platten
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  2. Lawrence Steinman
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Platten, M., Steinman, L. Multiple sclerosis: trapped in deadly glue. Nat Med 11, 252–253 (2005). https://doi.org/10.1038/nm0305-252

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