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Sensing the danger in RNA

Using siRNA-mediated intereference in a therapeutic setting will require a close examination of a disturbing side effect: under some circumstances, the technique induces an immune response. Signaling through a toll-like receptor is now implicated in this response in plasmacytoid dendritic cells (pages 263–270).

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Figure 1: A feeling for the nucleotides.

Ann Thomson

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Robbins, M., Rossi, J. Sensing the danger in RNA. Nat Med 11, 250–251 (2005). https://doi.org/10.1038/nm0305-250

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