Two studies link signaling of the anticoagulant thrombomodulin–protein C pathway to successful implantation during pregnancy and protection from ischemic brain injury. The data call for a reassessment of the causes of pre-eclampsia, and also provide hope for a new type of stroke therapy (pages 331–337 and 338–342).
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Ruf, W. PAR1 signaling: more good than harm?. Nat Med 9, 258–260 (2003). https://doi.org/10.1038/nm0303-258
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DOI: https://doi.org/10.1038/nm0303-258
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