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Gazing into a crystal ball–cancer therapy in the post-genomic era

The sequencing of the human genome is likely to speed the discovery of factors involved in cancer pathogenesis and lead to an age of individually tailored anti-cancer drugs. But does the ability to obtain an abundance of genetic information mean that we necessarily know how to use it?

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Figure 1: The pathway of anticancer agent development (periphery) and the possible contribution of the completed human genome sequence.

References

  1. International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001).

  2. Cringely, R.X. The five rules of prognostication. Forbes ASAP (November 30, 1998).

    Google Scholar 

  3. The International SNP Map Working Group. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature 409, 928–933 (2001).

  4. Yu, A. et al. Comparison of human genetic and sequence-based physical maps. Nature 409, 951–953 (2001).

    Article  CAS  Google Scholar 

  5. Collins, F.S. Shattuck lecture—medical and societal consequences of the human genome project. N. Engl. J. Med. 341, 28–37 (1999).

    Article  CAS  Google Scholar 

  6. Shields, P.G. & Harris, C.C. Cancer risk and low-penetrance susceptibility genes in gene-environment interactions. J. Clin. Oncol. 18, 2309–2316 (2000).

    Article  CAS  Google Scholar 

  7. Evans, W.E. & Relling, M.V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487–91 (1999).

    Article  CAS  Google Scholar 

  8. The BAC Resource Consortium. Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature 409, 953–958 (2001).

  9. Futreal, P.A. et al. Cancer and genomics. Nature 409, 850–852 (2001).

    Article  CAS  Google Scholar 

  10. Rowley, J.D. A new consistent chromosomal abnormality in chronic myelogenous leukemia. Nature 243, 290–293 (1973).

    Article  CAS  Google Scholar 

  11. Druker, B.J. & Lydon, N.B. Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemia. J. Clin. Invest. 105, 3–7 (2000).

    Article  CAS  Google Scholar 

  12. Elion, G.B. The purine path to chemotherapy. Science 24, 441–447 (1989).

    Google Scholar 

Download references

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Ratain, M., Relling, M. Gazing into a crystal ball–cancer therapy in the post-genomic era. Nat Med 7, 283–285 (2001). https://doi.org/10.1038/85414

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