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Zeroing in on tolerance

Nature Medicine volume 7, pages 279–281 (2001)Cite this article

Many genetic loci have been associated with autoimmune diseases through linkage analyses, but it has been a major challenge to isolate actual disease genes. The sequencing of the human genome and mapping of single nucleotide polymorphisms will speed the identification of these genes, and may also help explain how environmental factors such as bacteria and viruses can induce autoimmunity.

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Figure 1: The route from disease to the causative genetic variant is often a complex maze.

Bob Crimi

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Authors and Affiliations

  1. Division of Human Genetics, Departments of Genetics, Pediatrics and Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

    Anne M. Bowcock & Michael Lovett

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  1. Anne M. Bowcock
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  2. Michael Lovett
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Bowcock, A., Lovett, M. Zeroing in on tolerance. Nat Med 7, 279–281 (2001). https://doi.org/10.1038/85408

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