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Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation

Nature Medicinevolume 4pages208214 (1998) | Download Citation



The origin of CD4+ T cells reappearing in the blood following antiretroviral therapy in human immunodeficiency virus type-1 (HIV-1) infection is still controversial. Here we show, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4+ T-cell numbers reach a plateau. The increase in CD4+ T cells following therapy most likely is a composite of initial redistribution, accompanied by a continuous slow repopulation with newly produced naive T cells.

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Author information


  1. Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Plesmanlaan 125, 1066 CX, Amsterdam, The Netherlands

    • Nadine G. Pakker
    • , Marijke T.L. Roos
    • , Frank Miedema
    •  & Peter T.A. Schellekens
  2. Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    • Nadine G. Pakker
    • , Marijke T.L. Roos
    • , Frank Miedema
    •  & Peter T.A. Schellekens
  3. Division of Infectious Diseases, Tropical Medicine and AIDS and National AIDS Therapy Evaluation Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    • Daan W. Notermans
    •  & Sven A. Danner
  4. Theoretical Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    • Rob J. De Boer
  5. Department of Human Retrovirology, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    • Frank De Wolf
    •  & Frank Miedema
  6. Abbott Laboratories, Abbott Park, Illinois, 60064, USA

    • Andrew Hill
  7. Glaxo-Wellcome Research and Development, Greenford-Middlesex, UB6 0HE, United Kingdom

    • John M. Leonard
  8. Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands

    • Sven A. Danner
    •  & Peter T.A. Schellekens


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Correspondence to Frank Miedema.

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