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A T cell-independent antitumor response in mice with bone marrow cells retrovirally transduced with an antibody/Fc-γ chain chimeric receptor gene recognizing a human ovarian cancer antigen

Nature Medicinevolume 4pages168172 (1998) | Download Citation

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Abstract

In order to treat common cancers with immunotherapy, chimeric receptors have been developed that combine the tumor specificity of antibodies with T-cell effector functions. Previously, we demonstrated that T cells transduced with a chimeric receptor gene against human ovarian cancer were able to recognize ovarian cancer cells in vitro and in vivo. We now report that recipients of bone marrow cells transduced with these genes exhibited significant antitumor activity in vivo. Moreover, in vivo depletion of T cells in reconstituted mice did not affect antitumor activity, suggesting that other immune cells expressing the chimeric receptor gene may play an important role in tumor rejection.

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Author notes

    • Rajesh K. Chopra

    Present address: Osiris Therapeutics, Inc., 2001 Aliceanna Street, Baltimore, Maryland, 21231, USA

Affiliations

  1. Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B42, 10 Center Drive, Bethesda, Maryland, 20892, USA

    • Gang Wang
    • , Rajesh K. Chopra
    • , Richard E. Royal
    • , James C. Yang
    • , Steven A. Rosenberg
    •  & Patrick Hwu

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https://doi.org/10.1038/nm0298-168

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