Letters to the Editor | Published:

Improving AZT efficacy

Nature Medicinevolume 4page132 (1998) | Download Citation


Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Lavie, A. et al. The bottleneck in AZT activation. Nature Med. 3, 922–924 (1997).

  2. 2

    Balzarini, J. et al. The in vitro and in vivo anti-retro-virus activity, and intracellular metabolism of 3′-azido-2′,3′-dideoxythymidine and 2′,3′-dideoxy-cytidine are highly dependent on the cell species. Biochem. Pharmacol. 37, 897–903 (1988).

  3. 3

    Balzarini, J., Herdewijn, P. & De Clercq, E. Differential patterns of intracellular metabolism of 2′,3′-didehydro-2′,3′-dideoxythymidine and 3′-azido-2′,3′-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. J. Biol. Chem. 264, 6127–6133 (1989).

  4. 4

    Frick, L.W. et al. Effects of 3′-azido-3′-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells. Biochem. Biophys. Res. Comm. 154, 124–129 (1988).

  5. 5

    Guettari, N., Loubiere, L., Brisson, E. & Klatzmann, D. Use of Herpes-simplex Virus Thymidine Kinase to Imporve the Antiviral Activity of Zidovudine. Virology 235, 398–405 (1997).

  6. 6

    Meier, C., Habel, L., Laux, W., Declercq, E., & Balzarini, J. Homo Dinucleoside-alpha-hydroxyphosphonate Diesters as Prodrugs of the Antiviral Nucleoside Analogues 2′,3′-Dideoxythymidine and 3′-Azido-2′,3′Dideoxythymidine. Nudeosides & Nudeotides 14, 759–762 (1995).

  7. 7

    Lavie, A. et al. Crystal Structure of Yeast Thymidylate Kinase Complexed with the Bisubstrate Inhibitor P1-(5′-Adenosyl)P5-(5′-Thymidyl)Pentaphosphate (TP5A) at 2.0 Å Resolution: Implications for Catalysis and AZT Activation Biochem. In the press.

Download references

Author information


  1. Rega Institute for Medical Research, K.U.Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium

    • J. Balzarini
    • , B. Degrève
    •  & E. De Clercq


  1. Search for J. Balzarini in:

  2. Search for B. Degrève in:

  3. Search for E. De Clercq in:

About this article

Publication history

Issue Date



Further reading