Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Empowering T helper 17 cells in autoimmunity

The receptor for interleukin-7 is a susceptibility factor in multiple sclerosis, but its exact role in the disease has been unclear. New findings outline a function for interleukin-7 in the biology of T helper 17 cells, a subset of T cells recently identified as key players in autoimmune disorders (pages 191–197).

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Biphasic development and control of TH17.

Katie Vicari


  1. Gregory, S.G. et al. Nat. Genet. 39, 1083–1091 (2007).

    Article  CAS  Google Scholar 

  2. Hafler, D.A. et al. N. Engl. J. Med. 357, 851–862 (2007).

    Article  CAS  Google Scholar 

  3. Lundmark, F. et al. Nat. Genet. 39, 1108–1113 (2007).

    Article  CAS  Google Scholar 

  4. Liu, X. et al. Nat. Med. 16, 191–197 (2010).

    Article  CAS  Google Scholar 

  5. Cua, D.J. et al. Nature 421, 744–748 (2003).

    Article  CAS  Google Scholar 

  6. Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M. & Stockinger, B. Immunity 24, 179–189 (2006).

    Article  CAS  Google Scholar 

  7. Sutton, C., Brereton, C., Keogh, B., Mills, K.H. & Lavelle, E.C. J. Exp. Med. 203, 1685–1691 (2006).

    Article  CAS  Google Scholar 

  8. Teutsch, S.M., Booth, D.R., Bennetts, B.H., Heard, R.N. & Stewart, G.J. Eur. J. Hum. Genet. 11, 509–515 (2003).

    Article  CAS  Google Scholar 

  9. Zhang, Z. et al. Genes Immun. 6, 145–152 (2005).

    Article  CAS  Google Scholar 

  10. Seddon, B., Tomlinson, P. & Zamoyska, R. Nat. Immunol. 4, 680–686 (2003).

    Article  CAS  Google Scholar 

  11. Ramanathan, M. et al. J. Neuroimmunol. 116, 213–219 (2001).

    Article  CAS  Google Scholar 

  12. McGeachy, M.J. et al. Nat. Immunol. 10, 314–324 (2009).

    Article  CAS  Google Scholar 

  13. Sawa, Y. et al. Immunity 30, 447–457 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Marc Veldhoen.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Veldhoen, M., Seddon, B. Empowering T helper 17 cells in autoimmunity. Nat Med 16, 166–168 (2010).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing