An orally available drug enters the brain and interferes with signaling of orexin neuropeptides—providing a potential treatment for sleep disorders and possibly addiction (pages 150–155).
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References
Siegel, J.M. Annu. Rev. Psychol. 55, 125148 (2004).
Brisbare-Roch, C. et al. Nat. Med. 13, 150–155 (2007).
Peyron, C. et al. Nat. Med. 6, 991–997 (2000).
Thannickal, T.C. et al. Neuron 27, 469–474 (2000).
Crocker, A. et al. Neurology 65, 1184–1188 (2005).
Lee, M.G., Hassani, O.K. & Jones, B.E. J. Neurosci. 25, 6716–6720 (2005).
Mileykovskiy, B.Y., Kiyashchenko, L.I. & Siegel, J.M. Neuron 46, 787–798 (2005).
Estabrooke, I.V. et al. J. Neurosci. 21, 1656–1662 (2001).
Chemelli, R.M. et al. Cell 98, 437–451 (1999).
Beuckmann, C.T. et al. J. Neurosci. 24, 4469–4477 (2004).
Lin, L. et al. Cell 98, 365–376 (1999).
Mochizuki, T. et al. J. Neurosci. 24, 6291–6300 (2004).
Harris, G.C., Wimmer, M. & Aston-Jones, G. Nature 437, 556–559 (2005).
Hara, J., Yanagisawa, M. & Sakurai, T. Neurosci. Lett. 380, 239–242 (2005).
Narita, M. et al. J. Neurosci. 26, 398–405 (2006).
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Scammell, T., Saper, C. Orexins: looking forward to sleep, back at addiction. Nat Med 13, 126–128 (2007). https://doi.org/10.1038/nm0207-126
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DOI: https://doi.org/10.1038/nm0207-126
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