The phosphatase SHIP2 has been the focus of drug development efforts for diabetes. This distinction is based in part on work suggesting that the molecule is central to the regulation of glucose levels in tissues and blood. An analysis of a SHIP2 knockout mouse changes this viewpoint and provides new directions for therapeutic intervention (pages 199–205).
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Decker, S., Saltiel, A. Staying in SHIP shape. Nat Med 11, 123–124 (2005). https://doi.org/10.1038/nm0205-123
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DOI: https://doi.org/10.1038/nm0205-123
