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A Toll-like trigger for autoimmune disease

Autoimmune disease is set in motion by certain triggers, one of which now comes to light in a mouse model of type 1 diabetes. Signaling through Toll-like receptors, known for receiving signals from viruses and bacteria, initiates the disease (pages 138–145).

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Figure 1: The multiple potential effects of IFN-α on beta cell–specific autoimmune responses.

Kimberly Caesar

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Bach, JF. A Toll-like trigger for autoimmune disease. Nat Med 11, 120–121 (2005). https://doi.org/10.1038/nm0205-120

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