Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stemming the tide of rejection

Transplant recipients require chronic administration of drugs that suppress their immune system to prevent rejection of foreign tissues. The finding in rats that grafting embryonic stem-like cells to a transplant recipient can induce tolerance to transplants has important clinical implications. (pages 171–178)

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Two potential paths to mixed chimerism and transplantation tolerance.

References

  1. Fändrich, F. et al. Preimplantation-stage stem cells induce allogeneic graft tolerance without supplementary host conditioning. Nature Med. 8, 171–178 (2002).

    Article  Google Scholar 

  2. Sayegh, M.H. & Turka, L.A. The role of T cell co-stimulatory activation pathways in transplant rejection. N. Engl. J. Med. 338, 1813–1821 (1998).

    Article  CAS  Google Scholar 

  3. Sykes, M. Mixed chimerism and transplant tolerance. Immunity 14, 417–424 (2001).

    Article  CAS  Google Scholar 

  4. Ildstad, S.T. & Sachs, D.H. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 307, 168–170 (1984).

    Article  CAS  Google Scholar 

  5. Spitzer, T.R. et al. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation 68, 480–484 (1999).

    Article  CAS  Google Scholar 

  6. Editorial. Accepting stem cells. Nature Immunol. 2, 1085 (2001).

  7. Griffith, T.S., Brunner, T., Fletcher, S.M., Green, D.R. & Ferguson, T.A. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270, 1189–1192 (1995).

    Article  CAS  Google Scholar 

  8. George, J.F. et al. An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow. Nature Med 4, 333–335 (1998).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Adler, S., Bensinger, S. & Turka, L. Stemming the tide of rejection. Nat Med 8, 107–108 (2002). https://doi.org/10.1038/nm0202-107

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0202-107

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing