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Genetic models for CNS inflammation

Nature Medicine volume 7, pages 161–166 (2001)Cite this article

Abstract

The use of transgenic technology to over-express or prevent expression of genes encoding molecules related to inflammation has allowed direct examination of their role in experimental disease. This article reviews transgenic and knockout models of CNS demyelinating disease, focusing primarily on the autoimmune disease multiple sclerosis, as well as conditions in which an inflammatory response makes a secondary contribution to tissue injury or repair, such as neurodegeneration, ischemia and trauma.

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Figure 1: The major phases of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).

Stephen Horwitz

Figure 2: The multiple effects of cytokines in MS and EAE.

Stephen Horwitz

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Acknowledgements

T.O. thanks B. Finsen and J. Zimmer for their hospitality while writing this.

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Authors and Affiliations

  1. Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

    Trevor Owens & Jack Antel

  2. Max-Planck Institut for Neurobiology, Planegg-Martinsried, Germany

    Hartmut Wekerle

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Correspondence to Trevor Owens.

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Owens, T., Wekerle, H. & Antel, J. Genetic models for CNS inflammation. Nat Med 7, 161–166 (2001). https://doi.org/10.1038/84603

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