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From CRX to CRD

Nature Medicine volume 4, pages 18–19 (1998)Cite this article

Mutations in a homeodomain transcription factor that controls photoreceptor differentiation cause Cone-Rod Dystrophy, an inherited disease of retinal degeneration that results in blindness.

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References

  1. Rosenfeld, P., McKusick, V., Amberger, J. & Dryja, T. Recent advances in the gene map of inherited eye disorders: primary hereditary diseases of the retina, choroid and vitreous. J. Med. Genet 31, 903–915 (1994).

    Article  CAS  Google Scholar 

  2. Dryja, T.P. & Li, T. Molecular genetics of retinitis pig-mentosa. Hum. Mol. Genet. 4, 1739–1743 (1995).

    Article  CAS  Google Scholar 

  3. Berson, E.L., Pigmentosa: unfolding its mystery. Proc. Natl. Acad. Sci. USA 93, 4526–4528 (1996).

    Article  CAS  Google Scholar 

  4. Furukawa,T., Morrow, E.M. & Cepko, C.L., Crx, a novel otx-like homeobox gene, shows photorecep-tor-specific expression and regulates photoreceptor differentiation. Cell, 91, 531–541 (1997).

    Article  CAS  Google Scholar 

  5. Freund, C.L. et al. Cone-Rod Dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor. Cell 91, 551–553 (1997).

    Article  Google Scholar 

  6. Cepko, C.L., Austin, C., Yang, X., Alexiades, M. & Ezzedine, D. Cell fate determination in the vertebrate retina. Proc. Natl. Acad. Sci. USA 93, 589–595 (1996).

    Article  CAS  Google Scholar 

  7. Evans, K. et al. Genetic linkage of cone-rod retinal dystrophy to chromosome 19q and evidence for segregation distortion. Nature Genet. 6, 210–213 (1994).

    Article  CAS  Google Scholar 

  8. Freund, C.L., Horsford, D.J. & Mclnnes, R.R. Transcription factors and the developing eye: a genetic perspective. Hum. Mol. Genet. 5, 1471–1488 (1996).

    Article  CAS  Google Scholar 

  9. Oliver, G. & Gruss, P. Current views on eye development. Trends Neurosci. 20, 415–421 (1997).

    Article  CAS  Google Scholar 

  10. Rubboli, F. et al. A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms. Genes and Function 1, 205–213 (1997).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Faculté dé Medecine NECKER, CERTO, 75015, Paris, France

    Marc Abitbol & Jean-Louis Dufier

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  1. Marc Abitbol
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  2. Jean-Louis Dufier
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Abitbol, M., Dufier, JL. From CRX to CRD. Nat Med 4, 18–19 (1998). https://doi.org/10.1038/nm0198-018

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