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Live E. coli cells to treat uremia

Nature Medicine volume 3, pages 3–4 (1997)Cite this article

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References

  1. Prakash, S. & Chang, T.M.S. Microencapsulated genetically engineered live E. coli DH5 Cells administered orally to maintain normal plasma urea level in uremic rats. Nature Med. 2, 883–887 (1996).

    Article  CAS  Google Scholar 

  2. Altman, P.L. & Dittmer, D.S. Biological Handbooks: Blood and Other Body Fluids. (Federation of American Societies for Experimental Biology, Washington, DC, 1961).

    Google Scholar 

  3. Wrong, O.J., Edmonds, C. & Chadwick, V.S. The Large Intestine. (MTP Press, Lancaster, U. K. 1981).

    Google Scholar 

  4. Walser, M. Urea metabolism in chronic renal failure. J. Clin. Invest. 53, 1385–1392 (1974).

    Article  CAS  Google Scholar 

  5. Einheber, A., & Carter, D. The role of the microbiological flora in uremia. J. Exp. Med. 123, 239–250 (1966).

    Article  CAS  Google Scholar 

  6. Vince, A., Killingley, M. & Wrong, O.M. Effect of lactulose on ammonia production in a fecal incubation system. Gastoenterology 74, 544–549 (1978).

    CAS  Google Scholar 

  7. Rampton, D.S. et al. Treatment of chronic renal failure with dietary fiber. Clin. Nephrol. 21, 159–163 (1984).

    CAS  PubMed  Google Scholar 

  8. Parillo, M. et al. Metabolic consequences of feeding a high-carbohydrate, high-fiber diet to diabetic patients with chronic kidney failure. Am. J. Clin. Nutr. 48, 255–259 (1988).

    Article  CAS  Google Scholar 

  9. Platt, R., Margaret, H.R. & Smith, F.W. Experimental renal failure. Clin. Sci. 11, 217–228 (1951).

    Google Scholar 

  10. Prakash, S. & Chang, T.M.S. Preparation and in-vitro analysis of genetically engineered E. coli Cells, microencapsulated in artificial Cells for urea and ammonia removal. Biotechnol. Bioeng. 46, 687–697 (1995).

    Article  Google Scholar 

  11. Friedman, E.A. Future treatment of renal failure. in: Strategy in Renal Failure, (ed. Friedman, E. A.) 521ndash;528 (Wiley, New York, 1978).

    Google Scholar 

  12. Chang, T.M.S. Semipermeable microcapsules. Science 146, 524–525 (1964).

    Article  CAS  Google Scholar 

  13. Chang, T.M.S., Artifical Cells with emphasis on bioencapsulation in biotechnology. Biotechnol. Annu. Rev. 1, 267–295 (1995).

    Article  CAS  Google Scholar 

  14. Chang, T.M.S. Semipermeable aqueous micro-capsules (“artificial Cells”): with emphasis on experiments in an extracorporeal shunt system. Trans. Am. Soc. Artif. Intern. Org. 12, 13–19 (1966).

    CAS  Google Scholar 

  15. Chang, T.M.S. Microcapsule artificial kidney: including updated preparative procedures and properties. Kidney Int. 10, S218–S224 (1976).

    Google Scholar 

  16. Kjellstrand, C., Borges, H., Pru, C., Gardner, D. & Fink, D. On the clinical use of microencapsulated zirconium phosphate-urease for the treatment of chronic uremia. Trans. Am. Soc. Artif. Intern. Org. 27, 24–30 (1981).

    CAS  Google Scholar 

  17. Sparks, R.E. Review of gastrointestinal perfusion in treatment of uremia. Clin. Nephrol. 11, 81–87 (1979).

    CAS  Google Scholar 

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  1. Artificial Cells and Organs Research Centre McGill University, 3655 Drummond Street Montreal, Quebec, Canada, H3G 1Y6

    T.M.S. Chang

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  1. T.M.S. Chang
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Chang, T. Live E. coli cells to treat uremia. Nat Med 3, 3–4 (1997). https://doi.org/10.1038/nm0197-3b

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