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Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF–I system genes and partially restore behavioral function

Nature Medicine volume 2, pages 65–71 (1996)Cite this article

Abstract

Fetal grafts of normal cerebellar tissue were implanted into the cerebellum of Purkinje cell degeneration mutant mice (pcd/pcd), a model of adult–onset recessively inherited cerebello–olivary atrophy, in an attempt at correcting their cellular and motor impairment. Donor cerebellar cells engrafted in the appropriate sites, as evidenced by the pattern of expression of insulin–like growth factor–1 (IGF–I) system genes. Bilateral cerebellar grafts led to an improvement of motor behaviors in balance rod tests and in the open field, providing evidence for functional integration into the atrophic mouse cerebellum and underscoring the potential of neural transplantation for counteracting the human cerebellar ataxias.

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Authors and Affiliations

  1. Department of Anatomy, Indiana University School of Medicine, Indianapolis, Indiana, 46202, USA

    Wei Zhang & Wei-Hua Lee

  2. Department of Pediatrics and Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, 46202, USA

    Wei-Hua Lee

  3. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhlll Drive, MS-A128, Indianapolis, Indiana, 46202, USA

    Lazaros C. Triarhou

  4. Program in Medical Neurobiology, Indiana University School of Medicine, Indianapolis, Indiana, 46202, USA

    Lazaros C. Triarhou

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  3. Lazaros C. Triarhou
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Zhang, W., Lee, WH. & Triarhou, L. Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF–I system genes and partially restore behavioral function. Nat Med 2, 65–71 (1996). https://doi.org/10.1038/nm0196-65

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