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Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays

Nature Medicine volume 1, pages 84–88 (1995)Cite this article

Abstract

ATP-induced tumour growth inhibition is accompanied by a selective decrease in the content of the tripeptide glutathione (CSH) within the cancer cells in vivo. Depletion of cellular GSH sensitizes tumours to chemotherapy and radiation, but the usefulness of this depletion depends on whether the levels of GSH can be reduced in the tumour relative to normal tissues. We report here that administration of ATP in combination with diethylmaleate and X-rays leads to complete regression of 95% of Ehrlich ascites tumours in mice. This shows that an aggressive tumour can be eliminated by using a therapy based on modulation of GSH levels in cancer cells.

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Authors and Affiliations

  1. Departamento de Fisiologla, Universidad de Valencia, Facultad de Medicina, Av. Blasco Ibanez 17, 46010, Valencia, Spain

    José M. Estrela, Elena Obrador, José Navarro, M. Carmen Lasso De La Vega & José A. Pellicer

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  1. José M. Estrela
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  2. Elena Obrador
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  4. M. Carmen Lasso De La Vega
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  5. José A. Pellicer
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Estrela, J., Obrador, E., Navarro, J. et al. Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays. Nat Med 1, 84–88 (1995). https://doi.org/10.1038/nm0195-84

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