Caplen et al. (pages 39–46) demonstrate that it is feasible to use liposomes to transfer a human gene in vivo. Can this vector mimic the ability of viruses to effectively transfer genetic information into target cells?
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References
Caplen, N.J. et al. Nature Med. 1, 39–46 (1995).
Rommens, J.M. et al. Science 245, 1059–1065 (1989).
Riordan, J.R. et al. Science 245, 1066–1073 (1989).
Kerem, B.–S. et al. Science 245, 1073–1080 (1989).
Welsh, M.J. & Smith, A.E. Cell 73, 1251–1254 (1993).
Rosenfeld, M.A. et al. Cell 68, 143–155 (1992).
Crystal, R.G., Principal Investigator. Federal Register 58, 21737–21738 (1992).
Crystal, R.G. Personal communication, Recombinant DNA Advisory Committee. November 29, 1994.
Zabner, J. et al. Cell 75, 207–216 (1993).
Crystal, R.G. et al. Nature Genet. 8, 42–51 (1994).
Mastrangeli, A. et al. J clin Invest. 91, 225–234 (1993).
Rosenfeld, M.A. et al. Human Gene Therapy 5, 331–342 (1994).
Grubb, B.R. et al. Nature 371, 802–806 (1994).
Yang, Y. et al. Proc natn Acad Scl U SA. 91, 4407–4411 (1994).
Feigner, P.L. Liposome Res. 3, 3–16 (1993).
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Crystal, R. The gene as the drug. Nat Med 1, 15–17 (1995). https://doi.org/10.1038/nm0195-15
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DOI: https://doi.org/10.1038/nm0195-15
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