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A new entry route for HIV

Identification of HIV-1 variants capable of entering T cells via the CD8 receptor suggests a new mode of viral pathogenesis. But are these variants rare, aberrant viruses or a real problem? (pages 65–72)

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Figure 1: HIV-1 is known to infect cells that express CD4 and CCR5, such as T helper cells and macrophages.

Steve Horwitz

References

  1. Doms, R.W. Beyond receptor expression: The influence of receptor conformation, density, and affinity in HIV-1 infection. Virology 276, 229–237 (2000).

    Article  CAS  Google Scholar 

  2. Saha, K. et al. Isolation of primary (HIV-1) that target CD8+ T lymphocytes using CD8 as a receptor. Nature Med. 7, 65–72 (2000).

    Article  Google Scholar 

  3. Livingstone, W.J. et al. Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. The Lancet 348, 649–654 (1996).

    Article  CAS  Google Scholar 

  4. Semenzato, G. et al. CD8+ T lymphocytes in the lung of acquired immunodeficiency syndrome patients harbor human immunodeficiency virus type 1. Blood 85, 2308–2314 (1995).

    CAS  PubMed  Google Scholar 

  5. Tsubota, H. et al. CD8+ CD4lymphocyte lines can harbor the AIDS virus in vitro. J. Immunol. 143, 858–863 (1989).

    CAS  PubMed  Google Scholar 

  6. Margolick, J.B. et al. Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. Nature Med. 1, 674–680 (1995).

    Article  CAS  Google Scholar 

  7. Roederer, M. et al. CD8 naive T cell counts decrease progressively in HIV-infected adults. J. Clin. Invest. 95, 2061–2066 (1995).

    Article  CAS  Google Scholar 

  8. Herbein, G. et al. Apoptosis of CD8+ T-cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4. Nature 395, 189–194 (1998).

    Article  CAS  Google Scholar 

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Cullen, B. A new entry route for HIV. Nat Med 7, 20–21 (2001). https://doi.org/10.1038/83295

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