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Predicting leukemia relapse

Mass cytometry of acute B cell lymphoblastic leukemias at diagnosis reveals intrapatient phenotypic heterogeneity and specific signatures that mimic cell developmental stage and predict future relapse.

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Figure 1: A developmental-stage-dependent molecular classifier predicts relapse in B-ALL.

References

  1. Nowell, P.C. Science 194, 23–28 (1976).

    CAS  PubMed  Google Scholar 

  2. Ferrando, A.A. & López-Otín, C. Nat. Med. 23, 1135–1145 (2017).

    Article  CAS  Google Scholar 

  3. Hunger, S.P. & Mullighan, C.G. N. Engl. J. Med. 373, 1541–1552 (2015).

    Article  CAS  Google Scholar 

  4. Bhojwani, D. & Pui, C.H. Lancet Oncol. 14, e205–e217 (2013).

    Article  Google Scholar 

  5. Ma, X. et al. Nat. Commun. 6, 6604 (2015).

    Article  CAS  Google Scholar 

  6. Good, Z. et al. Nat. Med. 24, 474–483 (2018).

    Article  CAS  Google Scholar 

  7. Spitzer, M.H. & Nolan, G.P. Cell 165, 780–791 (2016).

    Article  CAS  Google Scholar 

  8. Behbehani, G.K. Clin. Lab. Med. 37, 945–964 (2017).

    Article  Google Scholar 

  9. Somasundaram, R., Prasad, M.A., Ungerbäck, J. & Sigvardsson, M. Blood 126, 144–152 (2015).

    Article  CAS  Google Scholar 

  10. Macaulay, I.C., Ponting, C.P. & Voet, T. Trends Genet. 33, 155–168 (2017).

    Article  CAS  Google Scholar 

  11. Frei, A.P. et al. Nat. Methods 13, 269–275 (2016).

    Article  CAS  Google Scholar 

Download references

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Correspondence to José Ignacio Martín-Subero.

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Martín-Subero, J. Predicting leukemia relapse. Nat Med 24, 385–387 (2018). https://doi.org/10.1038/nm.4529

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