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The intestinal microbiome influences checkpoint blockade

Nature Medicine volume 24, pages 254255 (2018) | Download Citation

Studies in metastatic melanoma, non-small-cell lung carcinoma and renal cell carcinoma indicate certain bacteria within the gut microbiota enhance clinical responses to checkpoint blockade.

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Author information

Affiliations

  1. Cynthia L. Sears and Drew M. Pardoll are at the Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins University School of Medicine, Balitmore, Maryland, USA.

    • Cynthia L Sears
    •  & Drew M Pardoll

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Competing interests

D.M.P. receives funding from Bristol–Myers Squibb and the Melanoma Research Alliance for immunotherapy research and consults for a number of companies with interests in immunotherapy, namely Compugen, GlaxoSmithKline, Medimmune/AstraZeneca, Merck, Potenza Therapeutics, Sanofi, Tizona, DNatrix, Amgen, Rock Springs Capital, Immunomic Therapeutics, Janssen, WindMil Therapeutics and Bayer. D.M.P. and C.L.S. are both supported by the Bloomberg-Kimmel Institute for Immunotherapy.

Corresponding author

Correspondence to Cynthia L Sears.

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DOI

https://doi.org/10.1038/nm.4511

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