Stem cell–derived human motor neurons were used to investigate the cellular mechanisms underlying C9ORF72-related amyotrophic lateral sclerosis.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 per month
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Chan, S., Kaufmann, P., Shungu, D.C. & Mitsumoto, H. Neuroimaging Clin. N. Am. 13, 307–326 (2003).
Leblond, C. S. et al. Exp. Neurol. 262 Pt B, 91–101 (2014).
Renton, A.E., Chiò, A. & Traynor, B.J. Nat. Neurosci. 17, 17–23 (2014).
Gitler, A.D. & Tsuiji, H. Brain Res. 1647, 19–29 (2016).
Shi, Y. et al. Nat. Med. 24, 313–325 (2018).
DeJesus-Hernandez, M. et al. Neuron 72, 245–256 (2011).
Lagier-Tourenne, C. et al. Proc. Natl. Acad. Sci. USA 110, E4530–E4539 (2013).
Mizielinska, S. et al. Science 345, 1192–1194 (2014).
Tran, H. et al. Neuron 87, 1207–1214 (2015).
Davidson, Y.S. et al. Acta Neuropathol. Commun. 2, 70 (2014).
Lin, C.L. et al. Neuron 20, 589–602 (1998).
Chow, C.Y. et al. Am. J. Hum. Genet. 84, 85–88 (2009).
Paşca, S.P. Nature 553, 437–455 (2018).
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Marton, R., Paşca, S. A human cellular model of amyotrophic lateral sclerosis. Nat Med 24, 256–257 (2018). https://doi.org/10.1038/nm.4509