Recognition of self-DNA drives cardiac inflammation: why broken hearts fail

Signals that govern immune cells in the heart remain poorly defined. A new report in mice shows that pathways involved in sensing viruses orchestrate monocyte and macrophage activation through recognition of DNA derived from dying cardiomyocytes following myocardial infarction.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: The role of cGAS–STING signaling in cardiac inflammation following myocardial infarction.

References

  1. 1

    Libby, P., Nahrendorf, M. & Swirski, F.K. J. Am. Coll. Cardiol. 67, 1091–1103 (2016).

  2. 2

    Wrigley, B.J., Shantsila, E., Tapp, L.D. & Lip, G.Y. Eur. J. Clin. Invest. 43, 121–130 (2013).

  3. 3

    Zhou, X. et al. Medicine (Baltimore) 95, e3466 (2016).

  4. 4

    Lu, W., Zhang, Z., Fu, C. & Ma, G. Int. Heart J. 56, 22–28 (2015).

  5. 5

    Shinagawa, H. & Frantz, S. Curr. Heart Fail. Rep. 12, 247–254 (2015).

  6. 6

    Swirski, F.K. Hamostaseologie 35, 34–36 (2015).

  7. 7

    Lavine, K.J. et al. Proc. Natl. Acad. Sci. USA 111, 16029–16034 (2014).

  8. 8

    King, K.R. et al. Nat. Med. 23, 1481–1487 (2017).

  9. 9

    Mann, D.L. Circ. Res. 116, 1254–1268 (2015).

  10. 10

    Chan, J.K. et al. J. Clin. Invest. 122, 2711–2719 (2012).

  11. 11

    Li, W., Moylan, J.S., Chambers, M.A., Smith, J. & Reid, M.B. Am. J. Physiol. Cell Physiol. 297, C706–C714 (2009).

Download references

Author information

Correspondence to Kory J Lavine.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Lavine, K., Mann, D. Recognition of self-DNA drives cardiac inflammation: why broken hearts fail. Nat Med 23, 1400–1401 (2017). https://doi.org/10.1038/nm.4455

Download citation

Further reading