Signals that govern immune cells in the heart remain poorly defined. A new report in mice shows that pathways involved in sensing viruses orchestrate monocyte and macrophage activation through recognition of DNA derived from dying cardiomyocytes following myocardial infarction.
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Lavine, K., Mann, D. Recognition of self-DNA drives cardiac inflammation: why broken hearts fail. Nat Med 23, 1400–1401 (2017). https://doi.org/10.1038/nm.4455
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DOI: https://doi.org/10.1038/nm.4455